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發表於 2008-5-8 22:03:33
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查到一篇，跟大家分享一下，
有關近來網路大量誤傳「九層塔會導致肝癌」一文，由本院毒物科吳明玲及葛謹醫師所署名，本院提出嚴正聲明，該文假借本院主治醫師名義散佈，且目前並無九層塔會導致癌症的研究報告，為避免社會大眾繼續被不實資訊誤導並引起恐慌，針對九層塔是否會導致肝癌，本院說明如下：
九層塔成分含有Eugenol（丁香酚）..........................繼續
另外找了一篇實驗報告，
落落長沒有耐心看，可以只看最後的 Comment
Comments
Acutely, high doses of eugenol are hepatoxic to dogs and rats.
Metabolic data is limited. Formation of small amounts of eugenol
2',3-epoxide from eugenol using in vitro systems has been reported.
Mutagenicity tests using Salmonella strains with and without
activation gave negative results for eugenol, although the
2',3-epoxide compound was active in these systems. Eugenol was not
carcinogenic in lifetime study in the rat. In a lifetime study with
B6C3F1 mice, there was evidence of an increased incidence of liver
tumours. Statistical analysis of the results suggested a positive
trend in male mice. Although the incidence of tumours in the female
mice was increased at the low dose level, the effect was not dose
related. The significance of this result is difficult to interpret and
has been judged to be equivocal. In this respect, it is important to
note that in studies in CDI mice which compared the carcinogenic
potential of eugenol with that of structurally-related compounds,
namely estrogal and suffrole, eugenol was negative, whereas suffrole
was positive. Thus most of the available evidence indicates that
eugenol is not carcinogenic.
No studies on teratology or reproduction are available.
The lifetime feeding study in the rat provides additional
information for evaluating an acceptable daily intake for man. This
data supports converting the previous temporary acceptable daily
intake to an acceptable daily intake.
還有最後的建議安全攝取量
EVALUATION
Level causing no toxicological effect
Rat: 250 mg/kg bw in the diet.
Estimates of acceptable daily intake for man
0-2.5 mg/kg bw
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原來真的什麼東西都是不能吃過量的.....
[ 本文最後由 mmarta 於 2008-5-10 04:26 編輯 ] |
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(看偶有多熱說)